Introducing

Gene Traffic Control™ Product Platform

At an airport, air traffic control directs hundreds of planes on when, where, and in what order they should move. If the control tower’s communication broke down, the result would be catastrophic.

 

Like at the airport, our cells need a system to direct when, where, and in what order our genes are expressed. In other words, this system, called the chromatin regulatory system, orchestrates the movement of molecules that turn genes “on” and “off.”

 

With Gene Traffic Control™ Product Platform, Foghorn has developed a platform to precisely target and drug issues in this regulatory system.

Breakdown in this system is a major, unexplored cause of many serious diseases, including over 25% of cancers.

From Chromatin to

Gene Expression

For human DNA to fit within our cells, it’s compacted and packaged in the nucleus of the cell as a substance called chromatin. For our genes to be expressed, the chromatin needs to be opened up so our DNA’s instructions can be read. The chromatin regulatory system is responsible for the opening and closing of this chromatin, and hence impacts which genes express certain traits.

A New and Powerful
Platform

Foghorn has a broad platform based on the biology of the chromatin regulatory system. With our powerful Gene Traffic Control™ (GTC) Product Platform, we are harnessing our knowledge of this system to develop medicines.

Foghorn has already used the GTCTM Product Platform to develop new insights, rapidly advance over 10 programs, and create a discovery engine that will simultaneously yield many additional targets. With insight from our discovery engine, scientific founders, seasoned board and leadership team, this is just the beginning of an entirely new approach to regulate gene expression.

Publications

Centore, Sandoval, Mendes Soares, Kadoch and Man Chan. “Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies” TIGS 1709 August 29, 2020

 

Michel et al. “A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation” Nat. Cell Biol. 2018 Dec; 20(12): 1410–1420

 

Kadoch & Crabtree. “Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics” Science Advances 12 Jun 2015: Vol. 1, no. 5, e1500447

 

Hodges, Kirkland, and Crabtree. “The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer” Advance July 13, 2016

 

Valencia and Kadoch. “Chromatin regulatory mechanisms and therapeutic opportunities in cancer” Nat Cell Biol. 2019 Feb; 21(2): 152–161

 

Sandoval et al. “Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis” 2018, Molecular Cell 71, 554–566, August 16, 2018